Probing Irradiated DNA with the Perturbed Angular Correlation Method

E. Tsoulou; C. A. Kalfas; E. G. Sideris

doi:10.1667/0033-7587(2001)156[0181:PIDWTP]2.0.CO;2

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E. Tsoulou,¹ C. A. Kalfas,¹ E. G. Sideris²

¹aInstitute of Nuclear Physics,NCSR Demokritos, 153 10 Agia Paraskevi, Athens, Greece
²b Institute of Biology, NCSR Demokritos, 153 10 Agia Paraskevi, Athens, Greece

Abstract

Tsoulou, E., Kalfas, C. A. and Sideris E. G. Probing Irradiated DNA with the Perturbed Angular Correlation Method. Radiat. Res. 156, 181–185 (2001).

The technique of perturbed angular correlations of γ rays has been used to study the effects of radiation on DNA molecules. The samples are buffered solutions of calf thymus DNA exposed to various doses (0–80 Gy) of γ rays. Indium-111 is used as a probe. Rotational correlation times, τ_c, a parameter measuring the flexibility of a macromolecule, are obtained that show a dependence on radiation dose.

Citation Download Citation

E. Tsoulou, C. A. Kalfas, and E. G. Sideris "Probing Irradiated DNA with the Perturbed Angular Correlation Method," Radiation Research 156(2), 181-185, (1 August 2001). https://doi.org/10.1667/0033-7587(2001)156[0181:PIDWTP]2.0.CO;2

Received: 30 October 2000; Accepted: 1 April 2001; Published: 1 August 2001

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